Comparison of high- versus low-intensity community health worker intervention to promote newborn and child health in Northern Nigeria
Background: In Northern Nigeria, infant mortality rates are two to three times higher than in the southern states, and, in 2008, a partnership program to improve maternal, newborn, and child health was established to reduce infant and child mortality in three Northern Nigeria states. The program intervention zones received government-supported health services plus integrated interventions […]
Study protocol for promoting respectful maternity care initiative to assess, Measure and design interventions to reduce disrespect and abuse during childbirth in Kenya
Background: Increases in the proportion of facility-based deliveries have been marginal in many low-income countries in the African region. Preliminary clinical and anthropological evidence suggests that one major factor inhibiting pregnant women from delivering at facility is disrespectful and abusive treatment by health care providers in maternity units. Despite acknowledgement of this behavior by policy […]
Does early Vitamin B12 supplementation improve neurodevelopment and cognitive function in childhood and into school age: A study protocol for extended follow-ups from randomised controlled trials in India and Tanzania
Introduction: As many as 250 million children under the age of 5 may not be reaching their full developmental potential partly due to poor nutrition during pregnancy and the first 2 years of life. Micronutrients, including vitamin B12, are important for the development of brain structure and function; however, the timing, duration and severity of […]
Systems analysis and improvement to optimize pMTCT (SAIA): A cluster randomized trial
Background: Despite significant increases in global health investment and the availability of low-cost, efficacious interventions to prevent mother-to-child HIV transmission (pMTCT) in low- and middle-income countries with high HIV burden, the translation of scientific advances into effective delivery strategies has been slow, uneven and incomplete. As a result, pediatric HIV infection remains largely uncontrolled. A […]
Bridging the childhood epilepsy treatment gap in northern Nigeria (BRIDGE): Rationale and design of pre-clinical trial studies
Epilepsy is the most common serious childhood neurological disorder. In the low- and middle-income countries (LMICs) of Africa, children with epilepsy suffer increased morbidity and mortality compared to their counterparts in high-income countries, and the majority do not receive treatment – the childhood epilepsy treatment gap. Reports of the childhood epilepsy treatment gap in Africa […]
Evaluation of conditional cash transfers and mHealth audio messaging in reduction of risk factors for childhood malnutrition in internally displaced persons camps in Somalia: A 2 × 2 factorial cluster-randomised controlled trial
Background AU Cash: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly transfer programmes are increasingly used in humanitarian : contexts to help address people’s needs across multiple sectors. However, their impact on the key objectives of reducing malnutrition and excess mortality remains unclear. mHealth interventions show great promise in many areas of public health, but evidence for their impact on reducing the […]
Risk of psychological distress following severe obstetric complications in Benin: The role of economics, physical health and spousal abuse
Background: Little is known about the impact of life-threatening obstetric complications (‘near miss’) on women’s mental health in low- and middle-income countries. Aims: To examine the relationships between near miss and postpartum psychological distress in the Republic of Benin. Method: One-year prospective cohort using epidemiological and ethnographic techniques in a population of women delivering at […]
Effect of a mass radio campaign on family behaviours and child survival in Burkina Faso: a repeated cross-sectional, cluster-randomised trial
Background: Media campaigns can potentially reach a large audience at relatively low cost but, to our knowledge, no randomised controlled trials have assessed their effect on a health outcome in a low-income country. We aimed to assess the effect of a radio campaign addressing family behaviours on all-cause post-neonatal under-5 child mortality in rural Burkina […]
The health system costs of post abortion care in Tanzania
Background: Unsafe abortion is common in Tanzania. Currently, postabortion care (PAC) is legally provided, but there is little information on the national cost. We estimated the health system costs of offering PAC in Tanzania in 2018, at existing levels of care and when hypothetically expanded to meet all need. Methods: We employed a bottom-up costing […]
Five years of malaria control in the continental region, Equatorial Guinea
Background: A successful malaria control programme began in 2004 on Bioko Island, Equatorial Guinea. From 2007, the same multiple malaria interventions, though reduced in scope for funding reasons, were introduced to the four mainland provinces of Equatorial Guinea (the continental region) aiming to recreate Bioko’s success. Two provinces received long-lasting insecticidal nets (LLINs) and two […]
