An assessment of hospital maternal health services in northern Ghana: a cross-sectional survey
Background: Access to and delivery of comprehensive emergency obstetric and neonatal care (CEmONC) services are often weak in low and middle-income countries affecting maternal and infant health outcomes. There are no studies on resources for maternal healthcare in the Northern region of Ghana. This knowledge is vital for health service planning and mobilising funding to […]
Prompt access to effective malaria treatment among children under five in sub-Saharan Africa: A multi-country analysis of national household survey data
Background: Scaling up diagnostic testing and treatment is a key strategy to reduce the burden of malaria. Delays in accessing treatment can have fatal consequences; however, few studies have systematically assessed these delays among children under five years of age in malaria-endemic countries of sub-Saharan Africa. This study identifies predictors of prompt treatment with first-line […]
Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi
Aim: This study was designed to determine whether faecal regenerating 1B protein (REG1B) concentration is associated with physical growth among 6–30-month-old children in rural Malawi. Methods: This was a secondary analysis from a randomised controlled trial in rural Malawi in which we followed-up 790 live-born infants from birth to 30 months of age. We collected […]
Maternal but not infant anti-HIV-1 neutralizing antibody response associates with enhanced transmission and infant morbidity
A significant number of infants acquire HIV-1 through their infected mother’s breast milk, primarily due to limited access to antiretrovirals. Passive immunization with neutralizing antibodies (nAbs) may prevent this transmission. Previous studies, however, have generated conflicting results about the ability of nAbs to halt mother-to-child transmission (MTCT) and their impact on infant outcomes. This study […]
Strategies to improve male involvement in PMTCT Option B+ in four African countries: A qualitative rapid appraisal
Background: The World Health Organization recommends that antiretroviral therapy be started as soon as possible, irrespective of stage of HIV infection. This ‘test and treat’ approach highlights the need to ensure that men are involved in prevention of mother-to-child HIV transmission (PMTCT). This article presents findings from a rapid appraisal of strategies to increase male […]
Drivers of food consumption among overweight mother-child dyads in Malawi
To address the increase in overweight and obesity among mothers and children in sub- Saharan Africa, an understanding of the factors that drive their food consumption is needed. We hypothesized food consumption in Malawi is driven by a combination of factors, including season, food accessibility (area of residence, convenience of purchasing food, female autonomy), food […]
Prevalence of stillbirth and its associated factors in East Africa: generalized linear mixed modeling
Background: Stillbirth is the most frequently reported adverse pregnancy outcome worldwide, which imposes significant psychological and economic consequences to mothers and affected families. East African countries account for one-third of the 2.6 million stillbirths globally. Though stillbirth is a common public health problem in East African countries, there is limited evidence on the pooled prevalence […]
Incidence of infant mortality and its predictors in East Africa using Gompertz gamma shared frailty model
Background: Globally, infant mortality is a major public health concern and a sensitive indicator of countries’ socio-economic and health status. Despite the substantial reduction of under-five mortality in sub-Saharan African countries specifically in East Africa, the infant mortality rate remains highest and too far below to achieve the WHO target. As to our search of […]
Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women
Malaria in pregnancy predisposes to maternal anemia and low birth weight (LBW). We examined the possible roles of the cytokines tumor necrosis factor alpha (TNF-α) and gamma interferon (IFN-γ) in these adverse outcomes. We measured cytokine concentrations in placental, peripheral, and cord blood plasma in relation to malaria parasitemia and placental monocyte accumulation in 276 […]
Antenatal receipt of sulfadoxine-pyrimethamine does not exacerbate pregnancy-associated malaria despite the expansion of drug-resistant plasmodium falciparum: Clinical outcomes from the queerpam study
Background. Antenatal intermittent preventive therapy with 2 doses of sulfadoxine-pyrimethamine (IPTp-SP) is the mainstay of efforts in sub-Saharan Africa to prevent pregnancy-associated malaria (PAM). Recent studies report that drug resistance may cause IPTp-SP to exacerbate PAM morbidity, raising fears that current policies will cause harm as resistance spreads.Methods.We conducted a serial, cross-sectional analysis of the […]
