Allium cepa Linn juice protect against alterations in reproductive functions induced by maternal dexamethsone treatment during lactation in male offspring of Wistar rats
Treatment with dams with dexamethasone during lactation has been reported to induce oxidative stress in the testis of the offspring. Allium cepa L (Red Onion) is known to be a potent free radical scavenger. The protective role of Allium cepa against oxidative stress induced in testis following treatment with dexamehasone during lactation in Wistar rats […]
Predictors of post neonatal mortality in Western Kenya: A cohort study
Introduction: to determine the predictors of mortality in infants in Siaya, western Kenya, ahead of novel tuberculosis (TB) vaccine trials in the same population. Methods: in a study to determine tuberculosis incidence, 2900 infants aged 0-45 days, weighing ≥ 1700g were enrolled. Four monthly follow up visits were conducted for at least 12 months. HIV […]
Comorbidities and Lack of Blood Transfusion May Negatively Affect Maternal Outcomes of Women with Obstetric Hemorrhage Treated with NASG
The Non-Pneumatic Anti-Shock Garment (NASG) is a first-aid device to reduce mortality from severe obstetric hemorrhage, the leading cause of maternal mortality globally. We sought to evaluate patient characteristics associated with mortality among a cohort of women treated with the NASG in Nigeria. Data on 1,149 women were collected from 50 facilities participating in the […]
Incidence of respiratory distress and its predictors among neonates admitted to the neonatal intensive care unit, Black Lion Specialized Hospital, Addis Ababa, Ethiopia
Background Although respiratory distress is one of the major causes of neonatal morbidity and mortality throughout the globe, it is a particularly serious concern for nations like Ethiopia that have significant resource limitations. Additionally, few studies have looked at neonatal respiratory distress and its predictors in developing countries, and thus we sought to investigate this […]
Cord blood hepcidin: Cross-sectional correlates and associations with anemia, malaria, and mortality in a tanzanian birth cohort study
Hepcidin, the master regulator of bioavailable iron, is a key mediator of anemia and also plays a central role in host defense against infection. We hypothesized that measuring hepcidin levels in cord blood could provide an early indication of interindividual differences in iron regulation with quantifiable implications for anemia, malaria, and mortality-related risk. Hepcidin concentrations […]
Prove—pre‐eclampsia obstetric adverse events: Establishment of a biobank and database for pre‐eclampsia
Pre‐eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The burden of disease lies mainly in low‐middle income countries. The aim of this project is to establish a pre‐eclampsia biobank in South Africa to facilitate research in the field of pre‐eclampsia with a focus on phenotyping severe disease.The approach of our biobank […]
Community perceptions of pre-eclampsia and eclampsia in southern Mozambique
Background: Sub-Saharan Africa has the highest maternal mortality ratio at 500 deaths per 100,000 live births. In Mozambique maternal mortality is estimated at 249-480 per 100,000 live births and eclampsia is the third leading cause of death. The objective of this study was to describe the community understanding of pre-eclampsia and eclampsia, as a crucial […]
Lesotho’s Minimum PMTCT Package: Lessons learned for combating vertical HIV transmission using co-packaged medicines
Introduction: Mother-to-child transmission of HIV can be reduced to
Postdischarge mortality in children with acute infectious diseases: Derivation of postdischarge mortality prediction models
Objectives: To derive a model of paediatric postdischarge mortality following acute infectious illness. Design: Prospective cohort study. Setting: 2 hospitals in South-western Uganda. Participants: 1307 children of 6 months to 5 years of age were admitted with a proven or suspected infection. 1242 children were discharged alive and followed up 6 months following discharge. The […]
Hypertension persisting after pre-eclampsia: A prospective cohort study at Mulago Hospital, Uganda
Background: Pre-eclampsia/eclampsia usually resolves after delivery but sometimes hypertension persists and cardiovascular disease develops later. Our objective was to determine the incidence and maternal socio-demographic and obstetric risk factors for persistence of hypertension in women with pre-eclampsia/eclampsia. Methods: This was a prospective cohort study conducted from July 2009 to June 2011 at Mulago Hospital labour […]
