A risk score to identify hiv-infected women most likely to become lost to follow-up in the postpartum period

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Study Justification:
The study aimed to address the issue of loss to follow-up (LTFU) among HIV-infected pregnant and breastfeeding women in sub-Saharan Africa. Access to antiretroviral therapy (ART) has been expanding in the region, but retention in HIV care is crucial for improving maternal HIV outcomes. By developing a risk score, the study aimed to identify women at high risk of becoming LTFU in the postpartum period. This information can help in targeting retention interventions and ensuring better continuity of care.
Highlights:
– The study used data from public health facilities in Lusaka, Zambia, to develop a risk score for identifying women at high risk of LTFU.
– Logistic regression analysis was used to assess various factors such as demographic, obstetric, and HIV-related predictors of LTFU.
– The study found that factors such as parity, education, employment status, WHO clinical stage, duration of ART during pregnancy, and number of antenatal care visits were associated with LTFU.
– A risk score approach was developed, which assigned scores based on these factors to predict the probability of LTFU.
– Different cut-points for the risk score were evaluated, with varying sensitivity and specificity values.
– A risk score cut-point of 11 (42nd percentile) had 85% sensitivity and 22% specificity, while a cut-point of 18 (69th percentile) had 32% sensitivity and 80% specificity.
– The study suggests that using a risk score approach can help in identifying a subset of women most likely to be LTFU, allowing for targeted retention interventions.
Recommendations:
– Implement the use of the developed risk score in HIV care programs targeting pregnant and breastfeeding women.
– Develop and implement retention interventions specifically tailored for women identified as high risk based on the risk score.
– Monitor and evaluate the effectiveness of the risk score and retention interventions in reducing LTFU rates among HIV-infected women in the postpartum period.
Key Role Players:
– Healthcare providers and staff involved in HIV care programs for pregnant and breastfeeding women.
– Policy makers and program managers responsible for implementing and overseeing HIV care services.
– Researchers and data analysts to monitor and evaluate the effectiveness of the risk score and retention interventions.
Cost Items for Planning Recommendations:
– Training and capacity building for healthcare providers on the use of the risk score and implementation of targeted retention interventions.
– Development and dissemination of guidelines and protocols for using the risk score in HIV care programs.
– Monitoring and evaluation activities to assess the impact of the risk score and retention interventions on reducing LTFU rates.
– Data collection and analysis to track the outcomes and effectiveness of the risk score approach.
– Communication and awareness campaigns to educate healthcare providers, policy makers, and the public about the importance of retention in HIV care for pregnant and breastfeeding women.

The strength of evidence for this abstract is 7 out of 10.
The evidence in the abstract is moderately strong. The study used logistic regression to assess various predictors of loss to follow-up (LTFU) in HIV care among pregnant women in Lusaka, Zambia. The sample size was relatively large (2029 pregnant women), and the study identified several factors associated with LTFU. However, the study only used data from public health facilities in one city, which may limit the generalizability of the findings. To improve the strength of the evidence, future studies could include data from multiple locations and consider a more diverse population. Additionally, conducting a prospective study to validate the risk score and assess its effectiveness in improving retention in HIV care would be beneficial.

Access to lifelong combination antiretroviral therapy (cART) is expanding among HIV-infected pregnant and breastfeeding women throughout sub-Saharan Africa (SSA). For this strategy to meaningfully improve maternal HIV outcomes, retention in HIV care is essential. We developed a risk score to identify women with high likelihood of loss to follow-up (LTFU) at 6 months postpartum from HIV care, using data from public health facilities in Lusaka, Zambia. LTFU was defined as not presenting for HIV care within 60 days of the last scheduled appointment. We used logistic regression to assess demographic, obstetric and HIV predictors of LTFU and to develop a simple risk score. Sensitivity and specificity were assessed at each risk score cut-point. Among 2029 pregnant women initiating cART between 2009 and 2011, 507 (25%) were LTFU by 6 months postpartum. Parity, education, employment status, WHO clinical stage, duration of cART during pregnancy and number of antenatal care visits were associated with LTFU (p-value <.10). A risk score cut-point of 11 (42nd percentile) had 85% sensitivity (95% CI 82%, 88%) and 22% specificity (95% CI 20%, 24%) to detect women LTFU and would exclude 20% of women from a retention intervention. A risk score cut-point of 18 (69th percentile) identified the 23% of women with the highest probability of LTFU and had sensitivity 32% (95% CI 28%, 36%) and specificity 80% (95% CI 78%, 82%). A risk score approach may be useful to triage a subset of women most likely to be LTFU for targeted retention interventions.

The recommendation to improve access to maternal health is to develop and implement a risk score system to identify HIV-infected women who are at high risk of becoming lost to follow-up in the postpartum period. This recommendation is based on a study conducted in Lusaka, Zambia, which found that 25% of pregnant women who initiated combination antiretroviral therapy (cART) were lost to follow-up by 6 months postpartum.

The risk score system would use demographic, obstetric, and HIV-related factors to assess the likelihood of a woman being lost to follow-up. These factors include parity, education, employment status, WHO clinical stage, duration of cART during pregnancy, and number of antenatal care visits. By assigning scores to each factor and calculating a total risk score, healthcare providers can identify women who are at high risk of being lost to follow-up.

The study found that a risk score cut-point of 11 (42nd percentile) had 85% sensitivity and 22% specificity to detect women who were lost to follow-up. This means that the risk score system could accurately identify 85% of women who would become lost to follow-up, but it would also include a significant number of women who would not be lost to follow-up. On the other hand, a risk score cut-point of 18 (69th percentile) identified the 23% of women with the highest probability of being lost to follow-up and had 32% sensitivity and 80% specificity. This means that this cut-point could accurately identify 32% of women who would become lost to follow-up and exclude 80% of women who would not be lost to follow-up.

Implementing a risk score system could help healthcare providers target retention interventions to the subset of women who are most likely to be lost to follow-up. By identifying these women early on, appropriate interventions can be put in place to ensure their continued access to HIV care and treatment. This innovation has the potential to improve maternal HIV outcomes by enhancing retention in HIV care during the postpartum period.

The recommendation and findings of this study were published in the journal AIDS Care – Psychological and Socio-Medical Aspects of AIDS/HIV in 2016.
AI Innovations Description
The recommendation to improve access to maternal health is to develop and implement a risk score system to identify HIV-infected women who are at high risk of becoming lost to follow-up in the postpartum period. This recommendation is based on a study conducted in Lusaka, Zambia, which found that 25% of pregnant women who initiated combination antiretroviral therapy (cART) were lost to follow-up by 6 months postpartum.

The risk score system would use demographic, obstetric, and HIV-related factors to assess the likelihood of a woman being lost to follow-up. These factors include parity, education, employment status, WHO clinical stage, duration of cART during pregnancy, and number of antenatal care visits. By assigning scores to each factor and calculating a total risk score, healthcare providers can identify women who are at high risk of being lost to follow-up.

The study found that a risk score cut-point of 11 (42nd percentile) had 85% sensitivity and 22% specificity to detect women who were lost to follow-up. This means that the risk score system could accurately identify 85% of women who would become lost to follow-up, but it would also include a significant number of women who would not be lost to follow-up. On the other hand, a risk score cut-point of 18 (69th percentile) identified the 23% of women with the highest probability of being lost to follow-up and had 32% sensitivity and 80% specificity. This means that this cut-point could accurately identify 32% of women who would become lost to follow-up and exclude 80% of women who would not be lost to follow-up.

Implementing a risk score system could help healthcare providers target retention interventions to the subset of women who are most likely to be lost to follow-up. By identifying these women early on, appropriate interventions can be put in place to ensure their continued access to HIV care and treatment. This innovation has the potential to improve maternal HIV outcomes by enhancing retention in HIV care during the postpartum period.

The recommendation and findings of this study were published in the journal AIDS Care – Psychological and Socio-Medical Aspects of AIDS/HIV in 2016.
AI Innovations Methodology
To simulate the impact of the main recommendations of this abstract on improving access to maternal health, you can follow these steps:

1. Identify the target population: Determine the specific population of HIV-infected pregnant women who would benefit from the risk score system. This could include women receiving antenatal care and initiating cART in a specific region or healthcare facility.

2. Collect data: Gather data on the demographic, obstetric, and HIV-related factors mentioned in the abstract, such as parity, education, employment status, WHO clinical stage, duration of cART during pregnancy, and number of antenatal care visits. This data can be obtained through medical records or surveys.

3. Develop the risk score system: Use logistic regression or another appropriate statistical method to analyze the collected data and develop a risk score system. Assign scores to each factor based on their association with loss to follow-up (LTFU) and calculate a total risk score for each woman.

4. Determine risk score cut-points: Determine the appropriate risk score cut-points based on the sensitivity and specificity values mentioned in the abstract. These cut-points will help identify women at high risk of being lost to follow-up.

5. Apply the risk score system: Apply the risk score system to the target population by calculating the risk scores for each woman. Identify women who meet the risk score cut-points and are at high risk of LTFU.

6. Implement targeted retention interventions: Develop and implement targeted retention interventions for the subset of women identified as being at high risk of LTFU. These interventions could include personalized counseling, reminder systems, peer support, or community outreach programs.

7. Monitor and evaluate outcomes: Continuously monitor and evaluate the impact of the risk score system and targeted interventions on improving access to maternal health. Track the number of women who remain engaged in HIV care during the postpartum period and assess any changes in LTFU rates.

8. Adjust and refine the system: Based on the outcomes and feedback from healthcare providers and patients, make any necessary adjustments or refinements to the risk score system and targeted interventions to further improve access to maternal health.

By following this methodology, you can simulate the impact of the risk score system on improving access to maternal health for HIV-infected women in the postpartum period.

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